Preparative HPLC Columns

An Interchim prep column will operate at lower pressure which translates into longer column life. The lower pressure is attributed to the removal of fines (<1µ diameter silica particles). The presence of fines in the column will gradually migrate to the outlet frit where they are trapped and cause pressure build up. Fines are removed from the bonded silica prior to packing the column. Compared to other manufacturers’ prep columns, an Interchim column will typically exhibit 30 – 40% lower pressure. Examples of lower pressure are found here. In each of the applications pressure never exceeded 30 bar/435 PSI.

Linear scale-up is achieved by developing an analytical method which uses the same bonded phase and particle size as the prep column. Alternatively, the analytical method can use the same bonded phase with a smaller particle on a shorter column.

After optimizing the separation on the analytical column, the appropriate prep column is selected based upon the desired sample load.

Small Molecule Purification

Uptisphere Strategy provides linear scale up from UHPLC to Prep. The high surface area silica (425 m²/g, 100Å) is available in a range of particle sizes to suit any budget: 2.2μ, 3μ, 5μ, 10μ and 15μ

Bio-Molecule Purification

Uptisphere X-Series is available in several pore sizes and bonded phases to address the wide range of selectivity required for biopurification.

上海劢穗德科学仪器有限公司MSD，专业代理经销色谱耗材产品，已13年以上的行业经验。